How Does Retatrutide Work?
Retatrutide is the first-of-its-kind triple agonist that works by:
- Activating GLP-1 receptors to control appetite and improve insulin sensitivity
- Stimulating GIP receptors to enhance metabolic function and fat loss
- Engaging glucagon receptors to increase energy expenditure and fat oxidation
This multi-pathway mechanism makes Retatrutide the most powerful weight-loss peptide yet, with effects that surpass other GLP-1-based therapies.
Usage & Administration
Retatrutide is administered via subcutaneous (SubQ) injection, typically once per week.
Typical Dosage Recommendations
- Starting Dose: 2.5 mg per week (for 4 weeks) to minimize side effects
- Titration Phase: Increase to 5 mg per week (weeks 5-8)
- Effective Weight Loss Dose: 7.5-15 mg per week, depending on response
- Maintenance Dose: 10-15 mg per week, adjusted as needed
Note: A gradual increase in dosage helps minimize side effects and allows for better adaptation.
As always, consult a medical professional before starting Retatrutide.
Is Retatrutide Safe?
Retatrutide is currently in advanced clinical trials and has demonstrated a strong safety profile with minimal side effects.
Potential Side Effects:
- Nausea, vomiting, & GI discomfort (common, typically subsides over time)
- Mild fatigue or dizziness
- Occasional constipation or diarrhea
- Rare risks include pancreatitis and thyroid issues (screening recommended before use)
Most side effects can be managed through dose titration and dietary modifications.